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KMID : 1007520030120060631
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Food Science and Biotechnology
2003 Volume.12 No. 6 p.631 ~ p.638
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Antioxidant, Antimutagenic and Chemopreventive Activities of a Phyto-extract Mixture Derived from Various Vegetables, Fruits, and Oriental Herbs
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Kim, Ji-Hoon
Kang, Boo-Hyon/Jeong, Jong-Moon
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Abstract
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A Phyto-extract mixture derived from various vegetables, fruits, and oriental herbs was screened for antioxidant, antimutagenic, and chemopreventive activities. The phyto-extract mixture exhibited greater scavenging effects on oxygen free radicals and 1, l-dipheny1-2-picry1-hydrazyl(DPPH) radicals than that of green tea, indicating its potential to reduce cancer-causing DNA mutation induced by highly reactive free radicals. The extracts showed a strong antimutagenic activity for the mutants induced by treatment of tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and benzo[α]pyren (B[α]P), exceeding that of the standard antimutagen, catechin. The phyto-extract mixture also showed chemopreventive activity, efficiently reducing NNK-induced lung cancer in A/J mice.
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KEYWORD
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